Carriero, Alessandra

Assistant Professor
Biomedical Engineering

Dr. Alessandra Carriero joined the Department of Biomedical Engineering of Florida Institute of Technology in 2014. Her research examines bone multi-scale mechanics and mechano-adaptation in growth, aging and disease with the aim to predict and prevent bone fractures and deformities, and aid in the development of new treatments for skeletal pathologies. Her interdisciplinary research combines mechanical engineering methods, material science approaches, high-resolution imaging, clinical data and biological analysis to reveal how mechanical forces influence bone growth, maintance and function. An enhanced understanding of the interplay between bone mechanical behaviour, composition, structure and biological function provides new and valuable insights into how healthy bone grows, ages, supports and adapts to loads avoiding deformations and fractures. Investigating how aging and disease change bone properties is of great clinical importance for developing therapies that can repair bone’s mechanical integrity. Dr. Carriero’s research has potential to make significant positive impact on the quality of life of patients while delivering economic benefits.

Educational Background

Ph.D., Biomechanics, Imperial College London

MSc., Biomedical Engineering, Politecnico di Milano

Erasmus Visiting Student, Trinity College Dublin

Recognition & Awards

Sir George Macfarlane Award, Royal Academy of Engineering, 2012

Travel Award, European Society of Biomechanics, 2012

Best Doctoral Thesis Award, European Society of Biomechanics – Finalist, 2011

Young Investigator Award, International Society of Biomechanics - Finalist, 2011

Clinical Biomechanics Award, International Society of Biomechanics - Finalist, 2011

Global Research Award, Royal Academy of Engineering, 2010

International Travel Award, Royal Academy of Engineering, 2009

Post-Graduate Research Scholarship, Bioengineering Department, Imperial College London 2005-2008

Best International Post-Graduate Research Award, University of Bologna, 2005

International Socrates-­Erasmus Scholarship, 2002-03

Undergraduate Scholarship, Politecnico di Milano, 1998-2004

Current Courses

BME 5710 Orthopaedic Biomechanics

Professional Experience

Assistant Professor, Florida Institute of Technology, Biomedical Engineering, 2014 - present

Research Associate, Imperial College London, Bioengineering, 2009 - 2014

Postdoctoral Fellow, Lawrence Berkeley National Laboratory, Materials Science Division, 2010 - 2011

Postdoctoral Fellow, ETH Zurich, Institute of Biomedical Engineering, 2009

Additional Duties

Professional Membership

Orthopaedic Research Society

American Society of Bone and Mineral Research

European Society of Calcified Tissue

European Society of Biomechanics

American Association of the Advancement Science

STEMNET UK

 

Scientific Journal Reviewer

Journal of Biomechanics, Journal of Endocrinology, Gait and Posture, Annals of Biomedical Engineering, Proceedings of the Institution of Mechanical Engineers, PLoS one, Computer Methods in Biomechanics and Biomedical Engineering, Clinical Biomechanics


Media Coverage of Research and Outreaching Activities

Cover of Journal of Bone and Mineral Research, June edition 2014

Cover of Bone journal, April edition 2014

Edtorial highlights of article ‘How tough is brittle bone? Investigating osteogenesis imperfecta mouse bone’ in the Journal of Bone and Mineral Research, January edition 2014

Demonstrator for ‘Cutting close to the bone’ - Fringe Event, Imperial College London with ‘Caramel bar or Dairy Milk? Use chocolate to explore brittle bone disease in mice’, November 2012

Scientific judge of elementary school children projects -­STEMNET Ambassador 2011

Writer of ‘Shaping our bones’. Plus Magazine, on-­line edition www.plus.maths.org/content/shaping-­our-­bones

Selected Publications

1. Carriero A., J.L. Bruse, K.J. Oldknow, J.L. Millan, C. Farquharson, S.J. Shefelbine. Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness, Bone, 2014; 69(12): 174-9

2. Carriero A., E.A. Zimmermann, S.J. Shefelbine, R.O. Ritchie. A methodology for the investigation of toughness and crack propagation in mouse bone. J Mech Behav Biomed Mater, 2014; 39: 38-47

3. Carriero A., L. Abela, A. Pitsillides, S.J. Shefelbine. Ex vivo determination of bone tissue strains for an in vivo mouse tibial loading model, J Biomech, 2014; 47(10): 2490-7

4. Carriero A., E.A. Zimmermann, A. Paluszny, S. Tang, H.A. Bale, B. Busse, T. Alliston, G. Kazakia, R.O. Ritchie, S.J. Shefelbine. How tough is brittle bone? Investigating osteogenesis imperfecta mouse bone, J Bone Miner Res, 2014; 29(6): 1392-401

5. Giorgi M., A. Carriero, S.J. Shefelbine, N.C. Nowlan. Mechanobiological simulations of prenatal joint morphogenesis. J Biomech, 2014; 47(5): 989-95

6. Carriero A., M. Doube, M. Vogt, B. Busse, J. Zustin, P. Schneider, R. Müller, S.J. Shefelbine. Altered lacunar and vascular porosity in osteogenesis imperfecta mice bone as revealed by synchrotron tomography contribute to bone fragility. Bone, 2014; 61(4): 116-24

7. Busse B., H.A. Bale, E.A. Zimmermann, B. Panganiban, H.D. Barth, A. Carriero, E. Vettorazzi, M. Hahn, J. Zustin, J.W. Ager, K. Puschel, M. Amling, R.O. Ritchie. Vitamin-D deficiency induces early signs of aging in human bone, increasing the risk of fracture. Sci Transl Med, 2013; 10(5): 193rad88

8. Carriero A., A. Zavatsky, J. Stebbins, T. Theologis, G. Lenaerts, I. Jonkers, S.J. Shefelbine. Influence of altered gait patterns on the hip joint contact forces. Comput Methods Biomech Biomed Engin, 2014; 14(4): 352-359

9. Carriero A., I. Jonkers, S.J. Shefelbine. Modelling proximal femur deformities in children with cerebral palsy. Comput Methods Biomech Biomed Engin, 2011; 14(3): 253-62

10. Carriero A., A. Zavatsky, J. Stebbins, T. Theologis, S.J. Shefelbine. Determination of gait patterns in children with spastic diplegic cerebral palsy using principal components. Gait Posture, 2009; 29(1): 71-5

11. Carriero A., A. Zavatsky, J. Stebbins, T. Theologis, S.J. Shefelbine. Correlation between lower limb bone morphology and gait characteristics in children with spastic diplegic cerebral palsy. J Paediatr Orthop, 2009; 29(1): 73-9