Fiedler, Tristan

Associate Vice President for Research - Federal Government Relations & Partnerships
Research

Educational Background

Bachelor of Science University of Miami 1991
Master of Science Rosenstiel School of Marine & Atmospheric Sciences, University of Miami 1994
Doctor of Philosophy Miller School of Medicine, University of Miami 2001

Postdoctoral Fellowships - Univ of Miami Medical School, Rosenstiel School of Marine & Atmospheric Science, & Cold Spring Harbor Laboratory

Current Courses

BIO 5990 - Biological Sciences Seminar

BIO 5991 - Biological Research Seminar

Professional Experience

Federal Research Programs at Florida Tech

The mission of Florida Institute of Technology’s Federal Research Programs Office is to advance extramural funding of research programs at Florida Tech. The Office will meet its objectives through effective internal collaboration, continuous professional development, and strong customer service expertise to our clients. The Office has responsibility for pre-award management of federal funding opportunities including

  • identification of research funding opportunities
  • review and assistance in proposal preparation
  • consultation with grants and contracts specialists to protect the University and it's researchers intellectual property
  • management of congressional appropriation requests


Florida Tech Consulting

Enabling businesses to begin new ways of thinking by developing innovative approaches to improve your company's performance

  • Responsible for all aspects of contracts and budgeting for faculty consulting opportunities
  • Business development in identification of new consulting relationships
  • Facilitate research & development consulting across all academic units at Florida Tech
  • Enhance local, regional and global businesses through
    • Increased profitability
    • Reduced operating costs
    • Increased efficiency
    • Improvements in technology, processes and methodology

Corporate Relations at Florida Tech

The mission of Florida Institute of Technology’s Corporate Relations Office is to increase corporate partnership through research contracts and philanthropic giving to the University. Through the Office of Research, we develop mutually beneficial, long-lasting relationships between the university and corporations whose research interests and consulting needs derive benefit from the academic expertise of Florida Tech faculty.

 

Academic Training


Prior to joining Florida Tech, Dr. Fiedler was an NIEHS postdoctoral fellow in the Marine & Freshwater Biomedical Science Center of the Rosenstiel School of Marine & Atmospheric Science of the University of Miami performing genomic analyses of Expressed Sequence Tags (ESTs) of Aplysia californica.

Dr. Fiedler then completed a research fellowship in bioinformatics at the Cold Spring Harbor Laboratory, Long Island, NY. While at CSHL, he created the online review of Caenorhabditis elegans biology, an open-access peer-reviewed multimedia resource available at www.WormBook.org. Dr. Fiedler is a founding member of the nematode Genome Annotation Assessment Project (www.wormbase.org/wiki/index.php/NGASP) which objectively assessed the accuracy of the current protein-encoding gene prediction algorithms in C. elegans, and to applied this knowledge to the annotation of the other Caenorhabditis genomes.

In addition to genomics research and teaching, Dr. Fiedler has performed extensive analyses of the X-ray crystal structure of human myeloperoxidase, a lysosomal protein stored in the azurophil granules of neutrophils. A second enzyme, oligoribonuclease, served as the focus for his initial postgraduate fellowship training. ORN is an essential enzyme in E. coli, responsible for the degradation of mRNA to mononucleotides.

Recently, the Federal Aviation Administration has funded Dr. Fiedler to serve as Academic Liaison to the FAA Center of Excellence for Commercial Space Transportation's Industrial Advisory Board (known as CESTAC). 

Current Research

In addition to the subjects listed above, Dr. Fiedler utilizes the following as both research and teaching tools.

DNA & Bioethics -- Human life begins with nearly 6 feet of a molecule so thin that a powerful electron microscope is needed to see its 3 billion base pairs spanning 46 chromosomes. This elegant simplicity is housed in a double helix forming the fundamental molecule of heredity. Science has transformed this simple structure into a biotechnology revolution. His interests focuses on the bioethical implications of understanding our genome sequence and of being able to artificially synthesize novel genomes, including those in stem cells, genetically modified food, and DNA vaccines.

Molecular Biology & Protein Structures -- In 1913, an orderly pattern of x-rays was observed emerging from a crystal. The following century has resulted in the elucidation of nearly 45,000 protein structures. Academic, pharmaceutical, and government laboratories are now racing to solve the most critical biomedical protein structures to get a precise picture of these molecules and regulate their activity when things go haywire during disease. Dr. Fiedler is interested in using structural biology in teaching and research programs to help students visual molecular biology.

Selected Publications

Tristan J. Fiedler, A. Hudder, S.J. McKay, S. Shivkumar, T.R. Capo, M.C. Schmale, P.J. Walsh. 2010. The transciptome of the early life history stages of the California Sea Hare Aplysia californica. Comp Biochem Phys D. Epub accepted 29 Mar 2010

Tristan J. Fiedler, Claudiu M. Nelersa, Yuhong Zuo, Adviye A. Tolun and Arun Malhotra. 2010. Structure of Oligoribonuclease is Optimized for Degradation of Small Oligonucleotidese. manuscript in preparation.

Tristan J. Fiedler, Darin Blasiar, Avril Coghlan, Paul Flicek, Todd W. Harris, Sheldon J. McKay, Lincoln D. Stein. 2008. nGASP: the nematode Genome Annotation Assessment Project. BMC Bioinformatics. 9(1):549

Rogers A, Antoshechkin I, Bieri T, Blasiar D, Bastiani C, Canaran P, Chan J, Chen WJ, Davis P, Fernandes J, Fiedler TJ, Han M, Harris TW, Kishore R, Lee R, McKay S, Mller HM, Nakamura C, Ozersky P, Petcherski A, Schindelman G, Schwarz EM, Spooner W, Tuli MA, Van Auken K, Wang D, Wang X, Williams G, Yook K, Durbin R, Stein LD, Spieth J, Sternberg PW. WormBase 2007. Nucleic Acids Res. 2008 Jan;36(Database issue):D612-7. Epub 2007 Nov 8.

Girard*, L. R., Fiedler*, T. J., Harris, T. W., Carvalho, F., Antoshechkin, I., Han, M., Sternberg, P. W., Stein, L. D., Chalfie, M. 2007. WormBook: the online review of C. elegans biology. NAR 35(Database issue):D472-5. Epub 2006 Nov 11. *equal contributors

Tamberlyn Bieri, Darin Blasiar, Philip Ozersky, Igor Antoshechkin, Carol Bastiani, Payan Canaran, Juancarlos Chan, Nansheng Chen, Wen J. Chen, Paul Davis, Tristan J. Fiedler, Lisa Girard, Michael Han,Todd W. Harris, Ranjana Kishore, Raymond Lee, Sheldon McKay, Hans-Michael Mueller, Cecilia Nakamura, Andrei Petcherski, Anthony Rogers, Gary Schindelman, Erich M. Schwarz, Will Spooner, Mary Ann Tuli, Kimberly Van Auken, Daniel Wang, Xiaodong Wang, Gary Williams, Richard Durbin, Lincoln D. Stein, Paul W. Sternberg, and John Spieth. . WormBase: New Content and Better Access. 2007. NAR 35(Database issue):D506-10. Epub 2006 Nov 11.

caBIG Data Sharing and Intellectual Capital Work Group. 2006. Proposed Policy for Sharing of Data Obtained in NIH Supported or Conducted Genome-Wide Association Studies (GWAS) - Response by caBIG. November 30, 2006. Response to Sally J. Rockey, Ph.D., Deputy Director for Extramural Research, NIH.

Schwarz EM, Antoshechkin I, Bastiani C, Bieri T, Blasiar D, Canaran P, Chan J, Chen N, Chen WJ, Davis P, Fiedler TJ, Girard L, Harris TW, Kenny EE, Kishore R, Lawson D, Lee R, Mller HM, Nakamura C, Ozersky P, Petcherski A, Rogers A, Spooner W, Tuli MA, Van Auken K, Wang D, Durbin R, Spieth J, Stein LD, Sternberg PW. WormBase: better software, richer content. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D475-8.

The WormBook Consortium. The Word on the Worm - Science NetWatch (April 14). 2006. 312: 169.

Fiedler, T. J., Vincent, H. A., Zuo, Y., Gavrialov, O., Malhotra A. 2004. Purification and Crystallization of E. coli oligoribonuclease. Acta Crystallographica D. D60:736-739.

Schrag, B., Ferrell, G., Weil, V., Fiedler, T. J. 2003. Barking up the wrong tree ? Industry funding of academic research. A case study with commentaries. Science & Engineering Ethics. 9(4):569-582.

Blair-Johnson, M., Fiedler, T., and Fenna, R. 2001. Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 Angstrom resolution. Biochemistry. 40: 13990-13997.

Davey, C., Fiedler, T., Fenna, R.E. 2000. Chapter 4: X-ray crystallographic studies of human myeloperoxidase. (in The Peroxidase Multigene Family of Enzymes: Biochemical Basis and Clinical Applications, Petrides, P.E. & Nauseef, W. M., editors) Springer Publishing Company, Heidelberg, New York. June 2000.

Fiedler, T. J., Davey, C. A., Fenna, R. E. 2000. X-ray crystal structure and characterization of halide binding sites of human myeloperoxidase at 1.8 Angstrom resolution. Journal of Biological Chemistry. 275(16): 11964 - 11971.

Zhang Y, Malinovskii VA, Fiedler TJ, Brew K. Role of a conserved acidic cluster in bovine beta1,4 galactosyltransferase-1 probed by mutagenesis of a bacterially expressed recombinant enzyme. Glycobiology. 1999 Aug;9(8):815-22.

Corollo D, Blair-Johnson M, Conrad J, Fiedler T, Sun D, Wang L, Ofengand J, Fenna R. Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):302-4. Epub 1999 Jan 1.