Brown, Alan

Associate Professor
Chemistry

Educational Background

B.A. Middlebury College 1979
Ph.D. University of Wisconsin, Madison 1986

Professional Experience

Dr. Brown was a National Institutes of Health postdoctoral fellow at Columbia University from 1986 to 1988, and came to Florida Tech in 1988.

Current Research

In collaboration with Dr. Baum, Dr. Brown is constructing molecules containing a carbazole ring (carbazoles fluoresce) and a quencher (acridine or pyridine), in mutual orientations that favor intramolecular hydrogen bonding. The presence of hydrazines or primary amines "turns on" the fluorescence of these molecules, allowing highly sensitive sensing of hydrazines and primary amines. (NASA)
In collaboration with Paul Kiprof (University of Minnesota, Duluth), Dr. Brown is carrying out extensive theoretical studies of annulated benzenes and Dewar benzenes. (Petroleum Research Fund)
Two new programs concern NMR analysis of nitrogen heterocycles, in collaboration with Ashraf Aly (El-Minia University, Egypt) and Scott McKay (University of Central Missouri).
Unconventional applications of NMR spectroscopy include whole-organism studies of live fish, in collaboration with Jon Shenker (Department of Biological Sciences).

Selected Publications

Aly, A.A., A.B. Brown, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, M.F. Radwan, M. Ramadan, and A.M. Gamal-Eldeen. 2012. Journal of Heterocyclic Chemistry 49:726-731.

Aly, A.A., A.A. Hassan, A.B. Brown, K.M. El-Shaieb, and T.M. Bedair. 2011. Facile synthesis of new imidazoles from direct reaction of 2,3-diamino-1,4-naphthoquinone with aldehydes. Journal of Heterocyclic Chemistry 48:787-791.

Aly, A.A., A.B. Brown, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, M.F. Radwan, M. Ramadan, and A.M. Gamnal-Eldeen. 2010. New synthesis of 4-oxo-thiazolidine-5-ylidenes of antitumor and antioxidant activities. Journal of Heterocyclic Chemistry 47:547-554.

Aly, A.A., A.B. Brown, M. Ramadan, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, M.F. Radwan, and A.M. Gamal-Eldeen. 2010. Selectivity of N-aroyl-N'-arylthioureas towards 2-[1,3-dioxo-1H-inden-2(3H)-ylidene]malononitrile. New synthesis of (Z)-N-{(E)-amino-1-aryl-5-cyano-6-oxo-1H-indeno[1,2-d][1,3]thioazepin-2(6H)-ylidene}4-arylamides of antitumor and antioxidant activities. Journal of Heterocyclic Chemistry 47:503-508.

Aly, A.A., A.B. Brown, M. Ramadan, A.M. Gamal-Eldeen, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, and M.F. Radwan. 2010. Thieno[2,3-d]pyrimidines in the synthesis of antitumor and antioxidant agents. Archiv der Pharmazie 343:301-309.

Aly, A.A., and A.B. Brown. 2009. Asymmetric and fused heterocycles based on [2.2]paracyclophane. Tetrahedron 65:8055-8089.

McKay, S.E., R.W. Lashlee III, L.W. Maina, K.A. Wheeler, and A.B. Brown. 2009. Synthesis of bipyridine N-oxides and bipyridine N,N'-dioxides. Heterocyclic Communications 15:181-188.

Aly, A.A., A.B. Brown, T.I. El-Emary, A.M.M. Ewas, and M. Ramadan. 2009. Hydrazinecarbothioamide group in the synthesis of heterocycles. Arkivoc (i)150-197.

Aly, A.A., A.B. Brown, K.M. El-Shaieb, A.A. Hassan, and T.M.I. Bedair. 2009. NMR study of the naphtho-1,3-dithioles formed from carbamodithioates and 2,3-dichloro-1,4-naphthoquinone. Journal of Chemical Research 689-691.

Aly, A.A., A.B. Brown, A.A. Hasaan, K.M. El-Shaieb, and T.M.I. Bedair. 2009. Carbamothioates in the synthesis of diaroyl sulfides; selectivity in the addition of diaroyl sulfides to acetylenic and ethylenic pi-deficient compounds. Arkivoc (xiii)66-77.

Aly, A.A., A.A. Hassan, M.A. Ameen, and A.B. Brown. 2008. Chemistry of cyclopropenones: synthesis of new pyrrolo[2,1-b]-1,3,4-oxadiazoles. Tetrahedron Letters 49:4060-4062.

Aly, A.A., A.A. Hassan, E.M. El-Sheref, M.A. Mohamed, and A.B. Brown. 2008. Conventional and microwave assisted synthesis of new 1,2,4-triazepine-3-thiones. Journal of Heterocyclic Chemistry 45:521-526.

McKay, S.E., R.S. Cole, and A.B. Brown. 2007/2008. Developing an undergraduate capstone course in the chemical sciences: a needed augmentation to the undergraduate research experience. Missouri Journal of Undergraduate Chemical Research 9:41-47.

Aly, A.A., A.M. NourEl-Din, M.A.-M. Gomaa, A.B. Brown, and M.S. Fahmi. 2007. Unusual reactivity of 2,3-diphenylcyclopropenone towards N-imidoylthioureas: facile synthesis of 3-aryl-2,5,6-triphenylpyrimidin-4(3H)-one (part III). Journal of Chemical Research 439-441.

Brown, A.B. 2005. Sustained safe environment: (photochemistry as) green chemistry. In "Environmental Studies: Implications for Sustainability", eds. G. Nelson and I. Hronszky; Arisztotelsz: Budapest; pp147-153.

Brown, A.B., T.L. Gibson, J.C. Baum, T. Ren and T.M. Smith. 2005. Fluorescence-enhancement sensing of ammonia and hydrazines via disruption of the internal hydrogen bond in a carbazolopyridinophane. Sensors and Actuators B 110:8-12.

Keglevich, Gy., H. Szelke, J. Kovcs, Gy. Marosi, A.B. Brown, S.C. Miller and C.L. Martin. 2005. Photofragmentations and photocycloadditions in the sphere of P-heterocycles. In "Science Supporting Environmental Protection", eds. G. Nelson and I. Hronszky; Arisztotelsz: Budapest; pp189-196.