Novak, Mark

Associate Professor

Educational Background

B.S. James Madison University
Ph.D. Florida State University

Current Research

Research focuses on discovering new ways to facilitate the use of enzymes for the stereo- and regioselective construction of organic molecules.

Currently, we are actively involved with:

• Expanding the synthetic utility of soybean lipoxygenase through the rational design, synthesis and evaluation of novel substrates.

• Using various organisms to model the human phase-I metabolism of candidate anti-parasitic drugs.

• Studying the metabolism of chemical warfare agents, such as mustard gas and nerve agents.

• Developing new synthetic methodology for the synthesis of novel enzyme substrates.

Complementing our basic research program are established collaborations in order to apply any novel technology to solve problems in toxicology, drug development, pharmacology and natural product synthesis.

Selected Publications

Bandekar, P.P.; Roopnarine, K.A.; Parekh, V.J.; Mitchell, T.R.; Novak, M.J.; Sinden, R.R. "AntimicrobialActivity of Tryptanthrins in E. coli" J. Med. Chem. 2010, 53, 3558.

Brimfield, A.A.; Mancebo, A.M.; Mason, R.P.; Jiang, J.J.; Siraki, A.G.; Novak, M.J. "Free Radical Production from the Interaction of Mustard Gas with Pyridine Nucleotide-Driven Flavoprotein Electron Transport System" Toxicol. Appl. Pharmacol. 2009, 234, 128-134.

Gilman, R.E.; Novak, M.J.; Baum, J.C.; Olson, J.A. "Scanning Tunneling Microscopy of 8-Fluoro[2,1-b]quinazolin-6,12-dione (8-Fluorotryptanthrin) at the Graphite-Solution Interface: Fully Resolved Molecular Orbitals" J. Phys. Chem. C 2008, 112, 14545-14548.

Moore, L.K.; Novak, M.J.; Santiago, J. "Modulation of Vascular Connexins by Stress Catecholamines and their Metabolites" FASEB J. 2007, 21.

Clapp, C.H.; Strulson, M.; Rodriguez, P.C.; Lo, R.; Novak, M.J. "Oxygenation of Monounsaturated Fatty Acids by Soybean Lipoxygenase-I: Evidence for Transient Hydroperoxide Formation" Biochemistry 2006, 45, 15884-15892.

Novak, M.J.; Baum, J.C.; Buhrow, J.W.; Olson, J.A. "Scanning Tunneling Microscopy of Indolo[2,1-b]quinazoline-6,12-dione on HOPG: Evidence of Adsorption-Induced Stereoisomerization"Sur. Science 2006, 600, L269-L273.