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Faculty Profiles

Brown, Alan

Associate Professor, Biomedical and Chemical Engineering and Sciences

Educational Background

B.A. Middlebury College 1979
Ph.D. University of Wisconsin, Madison 1986

Professional Experience

Dr. Brown was a National Institutes of Health postdoctoral fellow at Columbia University from 1986 to 1988, and came to Florida Tech in 1988.

Current Research

In collaboration with Dr. Baum, Dr. Brown is constructing molecules containing a carbazole ring (carbazoles fluoresce) and a quencher (acridine or pyridine), in mutual orientations that favor intramolecular hydrogen bonding. The presence of hydrazines or primary amines "turns on" the fluorescence of these molecules, allowing highly sensitive sensing of hydrazines and primary amines. (NASA)
In collaboration with Paul Kiprof (University of Minnesota, Duluth), Dr. Brown is carrying out extensive theoretical studies of annulated benzenes and Dewar benzenes. (Petroleum Research Fund)
Two new programs concern NMR analysis of nitrogen heterocycles, in collaboration with Ashraf Aly (El-Minia University, Egypt) and Scott McKay (Southern Arkansas University).
Unconventional applications of NMR spectroscopy include whole-organism studies of live fish, in collaboration with Jon Shenker (Department of Biological Sciences).

Selected Publications

Elkanzi, N.A.A., N.M. Morsy, A.A. Aly, A.B. Brown, and M. Ramadan, 2016. New pyrimidine-2-thiones from reactions of amidrazonethiols with 2-amino-1,1,2-ethenetricarbonitrile and investigation of their antitumor activity. Journal of Heterocyclic Chemistry 53:1838-1842.

Aly, A.A., M. Ramadan, M. Abd Al-Aziz, H.M. Fathy, S. Bräse, A.B. Brown, and M. Nieger, 2016. Reaction of amidrazones with 2,3-diphenylcyclopropenone: synthesis of 3-(aryl)-2,5,6-triphenylpyrimidin-4(3H)-ones. Journal of Chemical Research 40:637-639.

Aly, A.A., T. El Malah, E.A. Ishak, A.B. Brown, and W.M. Elayat, 2016. Tetracyanoethene and 1-amino-1,2,2-ethenetricarbonitrile in the synthesis of heterocycles of potential antioxidant and antibacterial activities. Journal of Heterocyclic Chemistry 53:963-969.

El Malah, T., A.A. Aly, S. Bräse, N.A.A. Elkanzi, and A.B. Brown, 2016. Reaction of dithiocarbamates with 2-[bis(methylthio)-methylene]malononitrile: unexpected formation of 4-imino-6-(methylthio)-3-substituted-3,4-dihydro-2H-1,3-thiazine-2-thiones. Journal of Sulfur Chemistry 37:222-228.

Aly, A.A., E.A. Ishak, T. El Malah, A.B. Brown, and W.M. Elayat, 2015. Synthesis of potentially antioxidant and antibacterial biologically active thiazolidines. Journal of Heterocyclic Chemistry 52:1758-1764.

Aly, A.A., A.B. Brown, A.A. Hassan, M.A.-M. Gomaa, and F.M. Nemr, 2015. Reaction of ethyl 2-cyano-3,3-bis(methylthio)acrylate with amidrazones: synthesis of new mercapto pyrazoles and NMR investigation. Journal of Sulfur Chemistry 36:502-510.

Hassan, A.A., A.A. Aly, K.M.A. El-Shaieb, T.M.I. Bedair, S. Bräse, and A.B. Brown, 2014. Synthesis of thiazolidin-4-ones from substituted (ylidene)hydrazinecarbothioamides and dimethyl acetylenedicarboxylate. Journal of Heterocyclic Chemistry 51:674-682.

Hassan, A.A., Y.R. Ibrahim, A.A. Aly, E.M. El-Sheref, and A.B. Brown, 2014. Synthesis of N-substituted(thiazol-2-ylidene)-pyrazol-5-amine derivatives via condensation of pyrazolylthioureas with w-bromoacetophenones. Journal of Heterocyclic Chemistry 51:610-617.

Aly, A.A., A.B. Brown, and A.A. Hassan. 2014. Heterocycles from the reaction of thione groups with acetylenic bonds. Advances in Heterocyclic Chemistry 113:245-304.

Aly, A.A., E.A. Ishak, and A.B. Brown. 2014. Reaction of arylidenehydrazono-4-aryl-2,3-dihydrothiazole-5-carbonitriles with diethyl acetylenedicarboxylate. Synthesis of (Z)-ethyl 2-[((Z)-2-(E)-arylidenehydrazono))-4-oxothiazolidine-5-ylidene]acetates. NMR investigation. Journal of Sulfur Chemistry 35:382-393.

Aly, A.A., N.A.A. Elkanzi, and A.B. Brown. 2014. Mini review of sulfur heterocyclization from pi-deficient quinones via charge-transfer interaction. Phosphorus, Sulfur, Silicon, and the Related Elements 189:440-452.

Hassan, A.A., A.A. Aly, T.I.M. Bedair, A.B. Brown, and T.I. El-Emary. 2014. A facile method for the synthesis of hydrazine-4-oxothiazolidine and imino-5-oxothiadiazine derivatives from 1,4-disubstituted thiosemicarbazides. Journal of Heterocyclic Chemistry 51:44-49.

Hassan, A.A., Y.R. Ibrahim, E.M. El-Sheref, A.A. Aly, S. Bräse, and A.B. Brown. 2012. Novel synthesis of pyrazolyloxothiazolidine derivatives. Journal of Heterocyclic Chemistry 49:1380-1385. 

Hassan, A.A., Y.R. Ibrahim, E.M. El-Sheref, and A.B. Brown. 2012. Novel synthesis of oxothiazolidine derivatives. Journal of Heterocyclic Chemistry 49:1054-1058.

Aly, A.A., A.B. Brown, T.M.I. Bedair, and E.A.-R. Ishak. 2012. Dithiocarbamate salts: their biological activity, preparation, and utility in organic synthesis. Journal of Sulfur Chemistry 33:605-617.

Aly, A.A., A.B. Brown, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, M.F. Radwan, M. Ramadan, and A.M. Gamal-Eldeen. 2012. An efficient synthesis of thiazolidin-4-ones with antitumor and antioxidant activities. Journal of Heterocyclic Chemistry 49:726-731.

Aly, A.A., A.A. Hassan, A.B. Brown, K.M. El-Shaieb, and T.M. Bedair. 2011. Facile synthesis of new imidazoles from direct reaction of 2,3-diamino-1,4-naphthoquinone with aldehydes. Journal of Heterocyclic Chemistry 48:787-791.

Aly, A.A., A.B. Brown, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, M.F. Radwan, M. Ramadan, and A.M. Gamnal-Eldeen. 2010. New synthesis of 4-oxo-thiazolidine-5-ylidenes of antitumor and antioxidant activities. Journal of Heterocyclic Chemistry 47:547-554.

Aly, A.A., A.B. Brown, M. Ramadan, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, M.F. Radwan, and A.M. Gamal-Eldeen. 2010. Selectivity of N-aroyl-N'-arylthioureas towards 2-[1,3-dioxo-1H-inden-2(3H)-ylidene]malononitrile. New synthesis of (Z)-N-{(E)-amino-1-aryl-5-cyano-6-oxo-1H-indeno[1,2-d][1,3]thioazepin-2(6H)-ylidene}4-arylamides of antitumor and antioxidant activities. Journal of Heterocyclic Chemistry 47:503-508.

Aly, A.A., A.B. Brown, M. Ramadan, A.M. Gamal-Eldeen, M. Abdel-Aziz, G.E.A.A. Abuo-Rahma, and M.F. Radwan. 2010. Thieno[2,3-d]pyrimidines in the synthesis of antitumor and antioxidant agents. Archiv der Pharmazie 343:301-309.

Aly, A.A., and A.B. Brown. 2009. Asymmetric and fused heterocycles based on [2.2]paracyclophane. Tetrahedron 65:8055-8089.

McKay, S.E., R.W. Lashlee III, L.W. Maina, K.A. Wheeler, and A.B. Brown. 2009. Synthesis of bipyridine N-oxides and bipyridine N,N'-dioxides. Heterocyclic Communications 15:181-188.

Aly, A.A., A.B. Brown, T.I. El-Emary, A.M.M. Ewas, and M. Ramadan. 2009. Hydrazinecarbothioamide group in the synthesis of heterocycles. Arkivoc (i)150-197.

Aly, A.A., A.B. Brown, K.M. El-Shaieb, A.A. Hassan, and T.M.I. Bedair. 2009. NMR study of the naphtho-1,3-dithioles formed from carbamodithioates and 2,3-dichloro-1,4-naphthoquinone. Journal of Chemical Research 689-691.

Aly, A.A., A.B. Brown, A.A. Hasaan, K.M. El-Shaieb, and T.M.I. Bedair. 2009. Carbamothioates in the synthesis of diaroyl sulfides; selectivity in the addition of diaroyl sulfides to acetylenic and ethylenic pi-deficient compounds. Arkivoc (xiii)66-77.

Aly, A.A., A.A. Hassan, M.A. Ameen, and A.B. Brown. 2008. Chemistry of cyclopropenones: synthesis of new pyrrolo[2,1-b]-1,3,4-oxadiazoles. Tetrahedron Letters 49:4060-4062.

Aly, A.A., A.A. Hassan, E.M. El-Sheref, M.A. Mohamed, and A.B. Brown. 2008. Conventional and microwave assisted synthesis of new 1,2,4-triazepine-3-thiones. Journal of Heterocyclic Chemistry 45:521-526.

McKay, S.E., R.S. Cole, and A.B. Brown. 2007/2008. Developing an undergraduate capstone course in the chemical sciences: a needed augmentation to the undergraduate research experience. Missouri Journal of Undergraduate Chemical Research 9:41-47.

Aly, A.A., A.M. NourEl-Din, M.A.-M. Gomaa, A.B. Brown, and M.S. Fahmi. 2007. Unusual reactivity of 2,3-diphenylcyclopropenone towards N-imidoylthioureas: facile synthesis of 3-aryl-2,5,6-triphenylpyrimidin-4(3H)-one (part III). Journal of Chemical Research 439-441.

Brown, A.B. 2005. Sustained safe environment: (photochemistry as) green chemistry. In "Environmental Studies: Implications for Sustainability", eds. G. Nelson and I. Hronszky; Arisztotelsz: Budapest; pp147-153.

Brown, A.B., T.L. Gibson, J.C. Baum, T. Ren and T.M. Smith. 2005. Fluorescence-enhancement sensing of ammonia and hydrazines via disruption of the internal hydrogen bond in a carbazolopyridinophane. Sensors and Actuators B 110:8-12.

Keglevich, Gy., H. Szelke, J. Kovcs, Gy. Marosi, A.B. Brown, S.C. Miller and C.L. Martin. 2005. Photofragmentations and photocycloadditions in the sphere of P-heterocycles. In "Science Supporting Environmental Protection", eds. G. Nelson and I. Hronszky; Arisztotelsz: Budapest; pp189-196.