Assistant Professor of Chemistry, Biomedical and Chemical Engineering and Sciences
Welcome to the Chouinard Research Group at Florida Tech! Work in this group involves ion mobility-mass spectrometry (IM-MS), a powerful technique that provides two separate dimensions of chemical separations information for improving confidence in identification and quantitation in metabolomics, lipidomics, and proteomics. Our projects range from instrument development to biological/clinical applications to fundamental studies of gas-phase chemistry and structure.
Dr. Chouinard was born and raised in the small town of Grafton, MA. His interests in chemistry and biology brought him south, where he attended University of North Carolina at Chapel Hill (Go Tar Heels!) and furthered his passion for analytical chemistry. After briefly working as a project manager for a contract research lab back in Massachusetts, Chris pursued his Ph.D. at the University of Florida. There, Chris worked under world renowned mass spectrometrist Rick Yost, and was responsible for integrating drift tube-ion mobility spectrometry (DTIMS) into the Yost lab. Chris's interests at UF involved IM-MS studies of clinical molecules (steroids, Vitamin D metabolites) and he also received grant funding through the Partnership for Clean Competition to develop novel IM-MS methods for improved identification of anabolic androgenic steroids in athletes.
After graduating from UF, Chris traveled to the opposite corner of the country to engage in a prestigious post-doctoral position at Pacific Northwest National Laboratory (PNNL) in Richland, WA. While working with Dick Smith, another world leader in mass spectrometry, Chris designed and developed a Structures for Lossless Ion Manipulations (SLIM) platform that enabled the first integration of LC into the SLIM IM-MS pipeline for improved analysis in phosphoproteomics.
Chris joined the faculty at Florida Tech in the summer of 2018 and will continue his work in ion mobility-mass spectrometry. Current projects involve improved methods for metabolomics and lipidomics with gas-phase chemistry.
University of Florida; Gainesville, FL August 2012 – August 2016
Ph.D., Analytical Chemistry
Research Advisor – Dr. Richard A. Yost
University of North Carolina at Chapel Hill; Chapel Hill, NC August 2006 – May 2010
B.S. Chemistry; B.S. Biology
Research Advisor – Dr. Mark H. Schoenfisch
2012-16 University Graduate Student Fellowship Recipient
2013 Townes R. Leigh Award for Outstanding Achievement by First Year Graduate Student
2015 Eastman Chemical Company Summer Fellowship
2016 Laitinen Award for Overall Excellence in Analytical Chemistry, UF
2016-17 MSACL US Young Investigator Award
2018 Agilent Steve Berger Award
2018 Agilent Global Academic Research Support Program
CHM 3301: Analytical Chemistry I
Florida Institute of Technology; Melbourne, FL August 2018 - Present
Assistant Professor, Chemistry
Pacific Northwest National Laboratory (PNNL); Richland, WA September 2016 - June 2018
Post-Doctoral Research Associate
Research Advisor – Dr. Richard D. Smith
1. Christopher D. Chouinard; Gabe Nagy; Ian K. Webb; Tujin Shi; Erin S. Baker; Spencer A. Prost; Tao Liu; Yehia M. Ibrahim; Richard D. Smith. “Improved Sensitivity and Separations of Phosphopeptides using Online LC Coupled with Structures for Lossless Ion Manipulations (SLIM) IM-MS,” 2018, Analytical Chemistry, In Press. DOI: 10.1021/acs.analchem.8b02397
2. Christopher D. Chouinard; Gabe Nagy; Ian K. Webb; Sandilya V.B Garimella; Erin S. Baker; Yehia M. Ibrahim; Richard D. Smith. “Rapid Ion Mobility Separations of Bile Acid Isomers using Cyclodextrin Adducts and Structures for Lossless Ion Manipulations,” 2018, Analytical Chemistry, In Press. DOI: 10.1021/acs.analchem.8b02990.
3. Gabe Nagy; Christopher D. Chouinard; Isaac K. Attah; Ian K. Webb; Sandilya V.B. Garimella; Yehia M. Ibrahim; Richard D. Smith; Erin S. Baker. “Development of a Cyclodextrin-Based Host-Guest Inclusion Complexation Strategy for the High-Resolution Separation of Enantiomeric Amino Acids on a Structures for Lossless Ion Manipulations Ion Mobility-Mass Spectrometry (SLIM IM-MS) Platform,” 2018, Electrophoresis, Invited Special Edition, In Press.
4. Christopher D. Chouinard; Vinicius W.D. Cruzeiro; Robin H.J. Kemperman; Nicholas R. Oranzi; Adrian E. Roitberg; Richard A Yost. “Cation-Dependent Conformations in 25-Hydroxyvitamin D3-Cation Adducts Measured by Ion Mobility-Mass Spectrometry and Theoretical Modeling,” International Journal of Mass Spectrometry, 2018, 43, 1-8. Invited Special Issue. DOI: 10.1016/j.ijms.2018.05.013
5. Christopher D. Chouinard; Vinicius W.D. Cruzeiro; Adrian E. Roitberg; Richard A Yost. “Experimental and Theoretical Investigation of Sodiated Multimers of Steroid Epimers with Ion Mobility-Mass Spectrometry,” Journal of the American Society for Mass Spectrometry, 2018, 28, 323-331. DOI: 10.1007/s13361-016-1525-7
6. Christopher D. Chouinard; Christopher R. Beekman; Robin H.J. Kemperman; Harrison M. King; Richard A Yost. “Ion Mobility-Mass Spectrometry Separation of Steroid Structural Isomers and Epimers,” International Journal for Ion Mobility Spectrometry, 2017, 20, 31-39. DOI: 10.1007/s12127-016-0213-4
7. Christopher D. Chouinard; Vinicius W.D. Cruzeiro; Christopher R. Beekman; Adrian E. Roitberg; Richard A Yost. “Investigating Differences in Gas-Phase Conformations of 25-Hydroxyvitamin D3 Sodiated Epimers using Ion Mobility-Mass Spectrometry and Theoretical Modeling,” Journal of the American Society for Mass Spectrometry, 2017, 28, 1497-1505. DOI: 10.1007/s13361-017-1673-4
8. Christopher D. Chouinard; Michael S. Wei; Christopher R. Beekman; Robin H.J. Kemperman; Richard A Yost. “Ion Mobility in Clinical Analysis: Current Progress and Future Perspectives,” Clinical Chemistry, 2016, 62, 124-133. Invited Special Issue; DOI: 10.1373/clinchem.2015.238840