B.A./M.A., Boston University, 1996
Ph.D., The University of Chicago, 2002
Recognition & Awards
AWARDS and HONORS
2008, Thieme Chemistry Journals Award (Germany)
2007, University of Miami Provost Award
2006, Summer Award in the Natural Sciences and Engineering, University of Miami
2006, University of Miami Provost Award
GRANTS and CONTRACTS
2012-2016, National Science Foundation, Chemical Synthesis Program
2007-2010, James and Esther King Biomedical Research Program
2007-2008, American Cancer Society IRG
I teach organic chemistry courses (CHM2001 & 2002) and a spectroscopy course (CHM5501).
Associate Professor, Florida Institute of Technology, 2015 —
Visiting Associate Professor, Florida Institute of Technology, 2014-2015
Assistant Professor, University of Miami, 2005-2014
Postdoctoral Fellow, University of Chicago, 2002-2005
In addition to teaching courses and conducting researches, I supervise the organic chemistry graduate teaching assistants and work with the chemistry stockroom staff to ensure that students learn as much as possible in the laboratory class.
Development of New Artificial Enzymes
Drug therapy is among the most successful and reliable treatments for various health issues. However, it is impeded by limitations in chemists’ ability to make the absolutely “correct” drug molecule in a timely and cost-effective manner. The development of artificial enzymes is a new approach in chemistry dedicated to the preparation of molecules with defined 3-D structure (molecular shape), and is of paramount importance to the drug discovery and development because the function of a drug is determined by its overall shape.
Researchers in the Takenaka Lab have developed a new class of artificial enzymes that shape-selectively synthesize molecules with the desired 3-D structure from easily available chemicals. Such technology will provide scientists ready access to precious medicinally active agents, and thus will not only accelerate the drug discovery process, but also lower costs of prescription drugs.
Synthesis of Natural Products
Natural products are the secondary metabolites (small organic molecules) produced in organisms and have long been the source of the great majority of drugs and drug candidates. Indeed, 78% of the antibacterial compounds and 74% of anticancer agents available today are either natural products or their chemical derivatives. The complete chemical synthesis of natural products is the first and key step in such drug discovery endeavors that aim to treat currently incurable diseases.
The researchers in the Takenaka Lab are currently working toward the complete chemical synthesis of the alkaloid Acutumine isolated from the moonseed Sinomenium acutum.
17) Narcis, M. J.; Takenaka, N. “Helical-Chiral Small Molecules in Asymmetric Catalysis” Eur. J. Org. Chem., 2014, 21-34. (This work was among the 25 most accessed articles of the year.)
16) Peng, Z.; Narcis, M. J.; Takenaka, N. “Enantio- and Periselective Nitroalkene Diels-Alder Reactions Catalyzed by Helical-Chiral Hydrogen Bond Donor Catalysts” Molecules, 2013, 18, 9982-9998.
15) Peng, Z.; Takenaka, N. “Application of Helical-Chiral Pyridines as Organocatalysts in Asymmetric Synthesis” The Chemical Record, 2013, 13, 28- 42.
14) Narcis, M. J.; Sprague, D. J.; Captain, B.; Takenaka, N. “Enantio- and periselective nitroalkene Diels-Alder reaction” Org. Biomol. Chem., 2012, 10, 9134-9136.
13) Chen, J.; Captain, B.; Takenaka, N. “Helical Chiral 2,2’-Bipyridine N-Monoxides as Catalysts in the Enantioselective Propargylation of Aldehydes with Allenyltrichlorosilane” Org. Lett., 2011, 13, 1654-1657.
12) Aguado, A.; Takenaka, N. “Intramolecular Nitroalkene Diels-Alder Reaction Catalyzed by Brønsted Acids” Synlett, 2011, 9, 1259-1261.
11) Takenaka, N.; Chen, J.; Captain, B.; Sarangthem, R. S.; Chandrakumar, A. “Helical Chiral 2-Aminopyridinium Ions: A New Class of Hydrogen Bond Donor Catalysts” J. Am. Chem. Soc. 2010, 132, 4536-4537. (Highlighted in Synfact 2010, 6, 712.)
10) Chen, J.; Takenaka, N. “Helical Chiral Pyridine N-Oxides: A New Family of Asymmetric Catalysts” Chem. Eur. J. 2009, 15, 7268-7276.
9) Takenaka, N.; Sarangthem, R. S.; Captain, B. “Helical-Chiral Pyridine N-Oxides, a New Family of Asymmetric Catalysts” Angew. Chem. Int. Ed. 2008, 47, 9708- 9710. (This work was among the 12 most accessed articles of the month.)
8) Takenaka, N.; Sarangthem, R. S.; Seerla, S. K. “2-Aminopyridinium Ions Activate Nitroalkenes through Hydrogen Bonding” Org. Lett., 2007, 9, 2819- 2822.
Undergraduate, Graduate and Postdoctoral Publications
7) Takenaka, N.; Abel, J. P.; Yamamoto, H. “Asymmetric Conjugate Addition of Silyl Enol Ethers Catalyzed by Tethered Bis(8-Quinolinolato) Aluminum Complexes” J. Am. Chem. Soc. 2007, 129, 742-743.
6) Unni, A. K.; Takenaka, N.; Yamamoto, H.; Rawal, V. H. “Axially Chiral Biaryl Diols Catalyze Highly Enantioselective Hetero-Diels-Alder Reactions through Hydrogen Bonding” J. Am. Chem. Soc. 2005, 127, 1336-1337.
5) Takenaka, N.; Xia, G.; Yamamoto, H. “Catalytic, Highly Enantio- and Diastereoselective Pinacol Coupling Reaction with a New Tethered Bis(8- quinolinolato) Ligand” J. Am. Chem. Soc. 2004, 126, 13198-13199.
4) Takenaka, N.; Huang, Y.; Rawal, V. H. “The First Catalytic Enantioselective Diels-Alder Reactions of 1,2-Dihydropyridine: Efficient Syntheses of Optically Active 2-Azabicyclo-[2.2.2]octanes with Chiral BINAM Derived Cr (III) Salen Complexes” Tetrahedron, 2002, 58, 8299-8305.
3) Hu, T.; Takenaka, N.; Panek, J. S. “Asymmetric Crotylation Reactions in the Synthesis of Polypropionate Derived Macrolide: Application to the Total Synthesis of Oleandolide” J. Am. Chem. Soc. 2002, 124, 12806-12815.
2) Hu, T.; Takenaka, N.; Panek, J. S. “Total Synthesis of Oleandolide” J. Am. Chem. Soc. 1999, 121, 9229-9230.
1) Jain, N. F.; Takenaka, N.; Panek, J. S. “Double-Stereodifferentiating Crotylation Reactions with Chiral (E)-Crotylsilanes. Evaluation of a New Approach for the Synthesis of Polypropionate-Derived Natural Products” J. Am. Chem. Soc. 1996, 118, 12475-12476.