Skip Navigation
Faculty Profiles

Faculty Profiles

Liao, Yi

Professor, Biomedical and Chemical Engineering and Sciences

Educational Background

Ph.D. Organic Chemistry,UniversityofMassachusetts,Amherst, 2001

B.S. in Chemistry, Nankai University, Tianjin, China, 1995

Current Courses

CHM 1101 General Chemistry 1

CHM 5550 Polymer Chemistry

CHM 5305 Electronic and Optical Materials (Special Topics in Analytical Chemistry)

Professional Experience

2018-present Professor, Florida Institute of Technology, Melbourne FL.

2013-2018 Associate Professor, Florida Institute of Technology, Melbourne FL.

2006-2013 Assistant Professor, University of Central Florida, Orlando, FL.

2002-2006 Postdoc University of Washington, Seattle, WA.

2001-2002 Postdoc UniversityofUtah, Salt Lake City, UT.

1999 Research Associate at Targacept company, Winston Salem, NC.

Current Research

Current research focuses on photoproton chemistry. Proton chemistry is the chemistry that is induced by proton transfer, which is one of the most fundamental processes in nature. Most of proton transfer processes are driven by a high concentration of proton, and many chemical, material, and biological processes are sensitive to proton concentration, from acid-catalyzed reactions to the activities of many enzymes. Using light to modulate proton concentration and proton transfer will allow us conduct these proton chemistry with remote, temporal and spatial control. Metastable-state photoacid, which was discovered by our group in 2011, is the only type of molecule that can reversibly produce a large proton concentration (pH change) under photoirradiation. Using metastable-state photoacids, one can not only initiate proton chemistry with light, but the process can also be stopped and/or reversed by turning off the light or using a different stimulus, e.g. heating or light with a different wavelength. This type of photoacid can be generally designed by coupling a reversible photoreaction with a proton dissociation process. We design and synthesize different types of metastable-state photoacids and the materials containing them, study the mechanisms of their photoreactions, and demonstrate their applications. The potential of metastable-state photoacids in controlling acid-catalyzed reactions, volume-change of hydrogels, polymer conductivity, bacterial killing, odorant release, color change, and polymer phase change have been demonstrated by our group. Other groups have also used this type of photoacid to control supramolecular assembly, polymerization reactions, microbial fuel cell, ATP production of chloroplast, ion channel, cationic sensor, molecular machine, just to name a few.

Our group is also working on carbon monoxide (CO) releasing materials (CORM). While carbon monoxide is well known as a toxic gas, it is actually a naturally-occurring vasodilator. Preclinical studies have shown that a controlled dose of carbon monoxide can reduce cardiovascular disorders and protect neuro cells. PhotoCORM, which releases CO upon irradiation allows remote, temporal and spatial control of CO release and thus has been intensively studied in recent years. Most CORMs including photoCORMs are metal carbonyls, which present a long-term health concern due to potential toxicity of the heavy metals. Our group reported the first organic photoCORMs in 2013. These photoCORMs can be activated by visible light, have potentially low toxicity, allow the delivery of carbon monoxide to be monitored by fluorescence imaging techniques, and thus are useful tools for the study of the biological functions of CO. Currently we are developing different nonmetallic CORMs and photoCORMs and incorporating them in tissue scaffold and polymer nanoparticles for biomedical applications.

updated August 2018

Selected Publications

1. Khalil, T.; Alharbi, A.; Baum, C.; Liao, Y. Facile Synthesis and Photoactivity of Merocyanine-Photoacid Polymers, Macromol. Rapid Commun. (2018) 1800319.
2. Abeyrathna, N.; Kenyatta W.; Bashur, C.; Liao, Y. Nonmetallic carbon monoxide releasing molecules (CORMs). Org. Bio. Mol. Chem. (2017) 15, 8692-8699.
3. Liao, Y. Design and Applications of Metastable-State Photoacids. Acc. Chem. Res. (2017), 50, 1956-1964.
4. Wang, Z.; Liao, Y., Reversible dissolution/formation of polymer nanoparticles controlled by visible light. Nanoscale (2016), 8, 14070-14073.
5. Abeyrathna, N.; Liao, Y., A reversible photoacid functioning in PBS buffer under visible light. J. Am. Chem. Soc. (2015), 137, 11282-11284.
6. Chen, H., Liao, Y., Photochromism based on reversible proton transfer, J. Photochem. Photobio., A: (2015), 300, 22-26.
7. Wang, Z.; Johns, V. K.; Liao, Y., Controlled Release of Fragrant Molecules with Visible Light. Chem. Eur. J. (2014), 20(45), 14637-14640.
8. Peng, P.; Wang, C.; Shi, Z.; Johns, V. K.; Ma, L.; Oyer, J.; Copik, A.; Igarashi, R.; Liao, Y., Visible-light activatable organic CO-releasing molecules (PhotoCORMs) that simultaneously generate fluorophores. Org. Biomol. Chem. (2013) 11, 6671-6674.
9. Shi, Z.; Peng, P.; Strohecker, D.; Liao, Y., A long-lived photoacid based upon a photochromic reaction. J Am. Chem. Soc. (2011) 133(37), 14699–14703.
10. Johns, V. K.; Shi, Z.; Dang, W.; McInnis, M. D.; Weng, Y.; Liao, Y. Photo retro-Diels-Alder reactions. J Phys. Chem. A. (2011), 115(28), 8093–8099.