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Karen Kim Guisbert

Research Assistant Professor | Biomedical Engineering and Science

Contact Information

Educational Background

B.S. in Biochemistry, University of Rochester, 1996

Ph.D. in Cell Biology, University of California, San Francisco, 2006

Professional Experience

Research Assistant Professor, Florida Institute of Technology, 2018-current

Research Professional, Florida Institute of Technology, 2014-2018

Research Assistant Professor, Northwestern University, 2013-2014

Research Scientist, Quidel Corp, 2013

Current Courses

BIO5573 Scientific Skills: Genome Annotation and Analysis

BIO4990 Biology Forum

BIO4991 Undergraduate Research

BIO5995 Biological Research (Graduate)

Selected Publications

Mossiah I, Perez SM, Stanley TR, Foley MK, Kim Guisbert KS, Guisbert E.  Geranylgeranylacetone Amerliorates Beta-Amyloid Toxicity and Extends Lifespan via the Heat Shock Response in Caenorhabditis elegans.  Front Aging. 2002 Apr 27;3:846977.

Golden NL, Foley MK, Kim Guisbert KS, Guisbert E.  Divergent regulatory roles of NuRD chromatic remodeling complex subunits GATAD2 and CHD4 in Caeenorhabditis elegans.  Genetics. 2022. May 5;221(1):iyac046.

Plagens RN, Mossiah I. Kim Guisbert KS, Guisbert E. Chronic temperature stress inhibits reproduction and disrupts endocytosis via chaperone titration in Caenorhabditis elegans.  BMC Biol. 2021 Apr 15;19(1):75.

Kim Guisbert KS, Mossiah I, Guisbert ETitration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology.  Int J Mol Sci. 2020 Dec 17;21(24):9641.

Golden NL, Plagens RN, Kim Guisbert KS, Guisbert E.  Standardized Methods for Measuring Induction of the Heat Shock Response in Caenorhabditis elegans.  J Vis Exp. 2020 Jul 3;(161).

Kim Guisbert KS, Guisbert E.  SF3B1 is a stress-sensitive splicing factor that regulates both HSF1 concentration and activity.  PLoS One. 2017 Apr 26; 12(4):e0176382.

Ma J, Grant CE, Plagens RN, Barrett LN, Kim Guisbert KS, Guisbert E.  Cellular proteomes drive tissue-specific regulation of the heat shock response.  G3 (Bethesda). 2017 Mar 10;7(3):1011-1018.

Hurtado S, Kim Guisbert KS, Sontheimer EJ.  SPO24 is a transcriptionally dynamic, small ORF-encoding locus required for efficient sporulation in Saccharomyces cerevisiae.  PLoS One. 2014 Aug 15;9(8):e105058.

Kim Guisbert KS, Sontheimer EJ.  Quit stalling or you'll be silenced.  Cell.  2013 Feb 28; 152(5):938-9.

Kim Guisbert KS, Zhang Y, Flatow J, Hurtado S, Staley JP, Lin S, Sontheimer EJ.  Meiosis-induced alterations in transcript architecture and noncoding RNA expression in S. cerevisiaeRNA.  2012 Jun; 18(6):1142-53. Epub 2012 Apr 26.

Kim Guisbert KS, Li H, Guthrie C.  Alternative 3’ pre-mRNA processing in S. cerevisiae is modulated by Nab4/Hrp1.  PLoS Biology2006 Dec 26:5(1)

Kim Guisbert, KS, Duncan K, Li H, Guthrie, C.  Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles.  RNA.  2005 Apr:11(4)383-93.  Epub 2005 Feb 9.

Preker PJ, Kim KS, Guthrie C.  Expression of the essential mRNA export factor Yra1p is autoregulated by a splicing-dependent mechanism.  RNA2002 Aug:8(8):969-80.

Roginskaya M, Connelly SM, Kim KS, Patel D, Dumont ME.  Effects of mutations in the N terminal region of the yeast G protein alpha-subunit Gpa1p on signaling by pheromone receptors.  Mol Genet Genomics.  2004 Mar:271(2):237-48.  Epub 2004 Feb 7.

Leavitt LM, Macaluso CR, Kim KS, Martin NP, Dumont ME.  Dominant negative mutations in the alpha-factor receptor, a G protein-coupled receptor encoded by the STE2 gene of the yeast Saccharomyces cerevisiaeMol Gen Genet1999 July:261(6):917-32

Recognition & Awards

American Cancer Society Postdoctoral Fellow, 2009-2012

Ruth L. Kirschstein National Research Service Award (declined), 2009

HHMI Predoctoral Fellowship, UCSF, 1999-2004

National Science Foundation Predoctoral Fellowship, UCSF (declined), 1999

Magna cum laude, University of Rochester, 1997

DeKiewiet Research Fellowship, University of Rochester, 1996

REU Summer Research Fellowship, University of Denver, 1995

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